It has long been thought that 6 smaller meals increases the amount of calories you burn vs 3 larger meals due to the  thermic effect of Food.

 

The Thermic Effect of Food is the amount of calories your body burns in order to metabolize the food you consume. 

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Protein Burns about 30% of its total calories, Carbohydrates bur about 15% and fat burns around 5%.

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According to multiple studies consuming smaller meals vs l

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References:
1. https://www.ncbi.nlm.nih.gov/pubmed/9155494
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033492/
3. https://www.ncbi.nlm.nih.gov/pubmed/26384657